Wei, Xian;Tan, Yang;Shi, Yuhe;Yuan, Yuan;Li, Shunmin
Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, 3015 Jiefang Rd, Shenzhen 518034, Guangdong, Peoples R China.
Chinese Herbal Med, Hunan Prov Engn Technol Ctr Standardizat & Funct, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
Hunan Univ Chinese Med, Pharm Coll, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
Zanthoxylum dissitum Hemsl;alkaloid;macrophages;NO
RECORDS OF NATURAL PRODUCTS
Hunan University of Chinese Medicine First-class Disciple Construction Project of Chinese Material Medica (China)
A new alkaloid glycoside (1) and six known alkaloids (2-7) were isolated from the stems of Zanthoxylum dissitum Hemsl. The structure of compound 1 was elucidated by UV, IR, H-1 NMR, C-13 NMR and mass spectroscopic analyses. All compounds obtained in this research were evaluated for their inhibitions against NO release from LPS-activated RAW264.7 macrophages. Compounds 1-3, 6 and 7 showed significant inhibition activities with IC50 values of 26.12 +/- 0.81, 8.41 +/- 0.23, 13.75 +/- 0.54, 6.97 +/- 0.77, and 5.78 +/- 0.42 mu M, respectively.