A New Alkaloid Glycoside from the Stems of Zanthoxylum dissitum Hemsl

  • SCI-E
作者: Wei, Xian;Tan, Yang;Shi, Yuhe;Yuan, Yuan;Li, Shunmin
作者机构: Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, 3015 Jiefang Rd, Shenzhen 518034, Guangdong, Peoples R China.
Chinese Herbal Med, Hunan Prov Engn Technol Ctr Standardizat & Funct, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
Hunan Univ Chinese Med, Pharm Coll, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
语种: 英文
关键词: Zanthoxylum dissitum Hemsl;alkaloid;macrophages;NO
期刊: RECORDS OF NATURAL PRODUCTS
ISSN: 1307-6167
年: 2021
卷: 15
期: 2
页码: 76-81
基金类别: Hunan University of Chinese Medicine First-class Disciple Construction Project of Chinese Material Medica (China)
摘要: A new alkaloid glycoside (1) and six known alkaloids (2-7) were isolated from the stems of Zanthoxylum dissitum Hemsl. The structure of compound 1 was elucidated by UV, IR, H-1 NMR, C-13 NMR and mass spectroscopic analyses. All compounds obtained in this research were evaluated for their inhibitions against NO release from LPS-activated RAW264.7 macrophages. Compounds 1-3, 6 and 7 showed significant inhibition activities with IC50 values of 26.12 +/- 0.81, 8.41 +/- 0.23, 13.75 +/- 0.54, 6.97 +/- 0.77, and 5.78 +/- 0.42 mu M, respectively.

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A New Alkaloid Glycoside from the Stems of Zanthoxylum dissitum Hemsl
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