Nanobody production and trimerization Nanobodies targeting SARS-CoV-2 spike protein were selected as previously described12,13. Genes of N-terminally PelB (MKYLLPTAAAGLLLLAAQPAMA)-tagged tandem homotr...
阅读全文Biosafety and ethics All work with infectious virus or infected animals was conducted in a biosafety level 4 (BSL-4) laboratory at the Centers for Disease Control and Prevention (CDC). All animal expe...
阅读全文During acute SARS-CoV-2 infection, viral mutations that are either neutral, detrimental, or beneficial can occur. Treatment with molnupiravir aims to surmount the threshold of tolerated detrimental mu...
阅读全文Twitter Facebook Email Access through your institution Buy or subscribe In the past decade or so, studies have shown that tumors — previously thought to be sterile — harbor bacterial communities...
阅读全文（通讯员 张倩倩）羊肚菌是世界名贵的珍稀食用菌，深受广大消费者的喜爱。2012年我国在羊肚菌大田外援营养袋栽培技术研发上取得突破，近年来栽培面积逐年增加。但羊肚菌生活史不清晰，基础生物学研究严重滞后，生产中...
阅读全文阿尔伯塔大学领导的一个研究小组称，大约600种看起来完全不同的真菌有一个共同的祖先，这些真菌从未在真菌家族树中找到合适的位置。该研究小组使用基因组测序为这些奇特的生物提供了自己的分类家。 “它们没有任何肉...
阅读全文We thank Dr. D. Houldershaw and Y. Goudetsidis for computer support at Birkbeck throughout the duration of the project. Cryo-EM samples were prepared and optimised at the ISMB EM facility at Birkbeck ...
阅读全文Some wolves in Yellowstone National Park, Wyoming, share territory with cougars — and can become infected with their parasites.Credit: mtnmichelle/Getty Wolves infected with a common parasite are mor...
阅读全文在许多超市食品中发现的糖替代品已被证明可以杀死导致肺炎和败血症的耐抗生素细菌。在健怡饮料、酸奶和甜点等产品中使用的三种人造甜味剂显著地阻止了耐多药优先病原体的生长。 这些添加剂不仅能使引起几种严重感染...
阅读全文Jillian Collins (bottom left) on a video call with her peer-mentoring group. In 2019, I started my PhD at Colorado School of Mines in Golden, conducting research on type 1 diabetes. It was a new labor...
阅读全文Animal husbandry The mouse experiments in this study were performed following the protocols (AN187712) approved by the Institutional Animal Care and Use Committee (IACUC) of the University of Californ...
阅读全文The new-cell-pole PodJ is a self-assembled protein Previous studies based on immunofluorescence microscopy analysis have suggested that PodJ asymmetrically localizes at the new cell pole of C. crescen...
阅读全文Vertebrate animals All work with vertebrate animals was approved by the Harvard Medical School Institutional Animal Care and Use Committee (IACUC). Isolation and culture of bovine articular chondrocyt...
阅读全文Mice CD90.1 (BALB/c), Foxp3hCD2 (C57BL/6J), and Irf3−/− (C57BL/6J)66 mice were bred and kept under SPF conditions in isolated ventilated cages at the Helmholtz Centre for Infection Research (Braunsc...
阅读全文武汉植物园揭示莲属植物种间花色分化的基因顺反式调控变异规律 近期，武汉植物园陈进明研究团队在植物学经典期刊Plant Physiology上发表了关于种间顺反式调控变异如何作用于莲属植物花色分化的研究论文。 ...
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