• 姓       名:刘东旭
  • 职       称:教授
  • 学       位:博士
  • 所在机构:湖北大学 生命科学学院
  • 出生年月:
  • 籍       贯:
  • E  - mail:dxliu@hubu.edu.cn
  • 研究方向:医学免疫学;医学生物化学;分子生物学
个人简介 学术成果 发表论文

教育背景

1997年 武汉同济医科大学医学 博士学位

工作经历

1996年 北京病毒基因工程国家重点实验室(侯云德院士)研究工作

1997年 中国科学院上海生物化学研究所(李载平院士)研究工作

1998年 美国波士顿大学 博士后研究工作

2001年 美国哈佛大学医学院 博士后研究工作

2002年 美国哈佛大学医学院 研究员

2007年 湖北大学生命科学学院 教授, 博士生导师

学术兼职

2006年 武汉理工大学湖北省生物材料工程技术研究中心 兼职教授

2007年 湖北省中药生物技术重点实验室学术委员会 学术委员

2007年 湖北省工业生物技术重点实验室 副主任

2007年 湖北省工业生物技术重点实验室学术委员会 学术委员

科研项目

1.国家自然科学基金面上项目(31070776),C5a受体介导血管内皮细胞损伤机制的研究,2011.1-2013.12,主持人

2.国家自然科学基金面上项目(30972769),补体调节蛋白质C1抑制物的新功能研究,2010.1-2012.12,主持人

3.国家自然科学基金国家合作项目(30811130467/C0302),蛋白水解酶系统作为癌症标记和癌症治疗的靶标,2008.9-2011.8,主要参与人

4.国家教育部回国留学基金(30811130467/C0302),补体调节蛋白质C1抑制物的研究 ,2008.9-2011.8,主持人

5.美国国立卫生研究院基金NIH-R01(2005-2010),C1 Inhibitor prevents endotoxin shock, 主要参与人

6.美国国立卫生研究院基金NIH-Phase I(2010-2011),Peptides from preventing sepsis, C1主要参与人

论文专著

1.Liu M, Xie M, Jiang S, Liu G, Li L, Liu D, Yang X. (2014) A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis. J Biotechnol. 186:1.

2.Yang X, Liu M, Zhang H, Xue B, Shi H, Liu D. (2014) Protein kinase C-δ Mediates Sepsis-induced Activation of Complement 5a and Urokinase-type Plasminogen Activator Signaling in Macrophages. Inflammation Research. 63:581.

3.Yang X, Wang X, Liu D, Yu L, Xue B, Shi H. (2014) Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b. Mol Endocrinol. 28:565.

4.Liu M, Huang Y, Hu L, Liu G, Hu X, Liu D, Yang X. (2012) Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion. BMC Biotechnol. 12:68.

5.Liu L, Qin XJ, Liu M, Zhang HM, Cheng ZD, and Liu D*. (2010) Silencing of C5a receptor gene with siRNA for protection from Gram-negative bacterial lipopolysaccharide-induced vascular permeability. Molecular Immunology. 47: 1325.

6.Hua D, Liu MY, Cheng ZD, Qin XJ, Zhang HM, Chen Y, Qin GJ, Liang G, Li JN, Han XF, and Liu D*. (2009) Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity. Molecular Immunology. 46:2876.

7.Zhou J, Zhu Y, Cheng M, Dinesh D, Thorne T, Poh KK, Liu D, Botros C, Tang YL, Reisdorph N, Kishore R, Losordo DW, Qin G. (2009) Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation. 120:1213.

8.Cheng Z, Liu M, Chen G, Zhang H, Qin G, Liang G, and Liu D*. (2008) Anti-vascular permeability of the cleaved reactive center loop within the carboxyl-terminal domain of C1 inhibitor. Molecular Immunology. 45:1743.

9.Davis AE III, Cai S, and Liu D*. (2007) C1 inhibitor: biologic activities that are independent of protease inhibition. Immunobiology. 212:313.

10.Wu Y, Tu X, Lin G*, Xia H, Huang H, Wan J, Fu J, Liu Q, Liang Q, Qin G, Zhang H, Zhang H, and Liu D*. (2007) Emodin-mediated protection from acute myocardial infarction in mice via inhibiting inflammation and apoptosis in local ischemic myocardium. Life Sciences. Life Sciences. 81:1332.

11.Liu D*, Qin G, Fernandes SM, Li J, and Davis III AE*. (2007) C1 Inhibitor-Mediated Protection from Sepsis. The Journal of Immunology. The Journal of Immunology. The Journal of Immunology. 179:3966.

12.Zhang H, Li J, Barrington RA, Liang G, Qin G, and Liu D*. (2007) An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitor. Biochemical and Biophysical Research Communication. 359:285.

13.Zhang H, Qin G, Liang G, Li J, Barrington RA, and Liu D*. (2007) Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action. Biochemical and Biophysical Research Communication. 358:1120.

14.Zhang H, Qin G, Liang G, Li J, Barrington RA, and Liu D*. (2007) C5aR-mediated myocardial ischemia/reperfusion injury. Biochemical and Biophysical Research Communication. 357:446.

15.Fu J, Lin G*, Zeng B, Wu Z, Wu Y, Chu H, Qin G, Liang G, Li J, Gan X, Yu X, Li C, and Liu D*. (2006) Anti-ischemia/reoxygenation of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochemical and Biophysical Research Communication. 350:162.

16.Fu J, Lin G*, Xiang Y, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, and Liu D*. (2006) Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochemical and Biophysical Research Communication. 349:504.

17.Liu D, Cramer CC, Scafidi J, and Davis AE III (2005). N-linked glycosylation Asn3 and the positively charged amino acids within the amino terminal domain of C1 inhibitor are required for its interaction of C1 inhibitor with Salmonella enterica Serovar Typhimurium lipopolysaccharide and lipid A. Infection and Immunity. 73:4478.

18.Liu D, Zhang D, Scafidi J, Cramer CC, Wu X, and Davis AE III. (2005) C1 inhibitor protects from lipopolysaccharide-induced vascular permeability. Blood. 105:2350.

19.Davis AE III, Cai S. and Liu D (2004) The biologic role of C1 inhibitor in regulation of vascular permeability and modulation of inflammation. Advances in Immunology. 82:331.

20.Liu D, Gu X, Scafidi J, and Davis AE III. (2004) N-linked glycosylation is required for C1 inhibitor-mediated protection from endotoxin shock in mice. Infection and Immunity. 74:1946.

21.Liu D, Cai S, Gu X, Scafidi J, Wu X, and Davis AE III. (2003) C1 Inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide. The Journal of Immunology, 171:2594.

22.Liu D, Scafidi J, Prada AE, Zahedi K, and Davis AE III. (2002) Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes. Biochemical and Biophysical Research Communication. 299:574.

23.Liu D and Waxman DJ. (2002) Posttranscriptional regulation of hepatic NADPH-P450 reductase by thyroid hormone: independent effect on Poly (A) tail length and mRNA stability. Molecular Pharmacology. 61:108.

24.Li H, Liu D, and Waxman DJ. (2001) Transcriptional induction of hepatic P450 reductase by thyroid hormone. Molecular Pharmacology. 59:987.

25.Guo T, Zhang Y, Liu D et al. (1999) Dauricine inhibits redistribution of platelet membrane glycoprotein IV and release of intracellular a-granule thrombospondin induced by thrombin. Acta Pharmacologica Sinica. 20:533.

26.Liu D, Shen Di, Zou P et al. (1997) Redistribution of platelet membrane glycoprotein IV (CD36) and release of intracellular a-granular thrombospondin in patients with chronic myelogenous leukemia, Journal of Tongji Medical University. 17:21.

27.Liu D, Peng D, Chen R et al. (1995) Chronic pulmonary infection caused by mycoplasma pneumoniae leading to pulmonary arteriole remodeling and pulmonary hypertension in rats. Journal of Tongji Medical University. 15:223.

专利成果

1. 刘东旭 人源胰岛素样生长因子结合蛋白1在毕氏酵母中的诱导表达及纯化方法、相关抗体制备和应用 201210531593.5

2.刘东旭 抗内毒素短肽在毕氏酵母中的诱导表达方法、表达的抗内毒素短肽及应用 201010585889.6

3.刘东旭 正常人和哺乳动物不同组织源性原代细胞分离的多酶体系、其用途和相关试剂盒 201010228374.0

4. 刘东旭 病人肿瘤组织源性原代细胞分离的多酶体系、其使用方法、用途和相关试剂盒 201010254756.0

5.刘东旭 自发性免疫性疾病特异性抗体和相关的自发性免疫性疾病诊断试剂盒 201010169506.7

6. 雷震、刘东旭 一种细胞长期培养保存三维系统及相关的细胞长期培养保存方法 200910194729

7. Davis AE III and Liu D Methods for treating and preventing sepsis using modified C1 Inhibitor or fragments thereof US2005288218

奖励/荣誉

1997年 中国科学技术协会自然科学论文优秀奖

2007年 湖北 “楚天学者”计划特聘教授

2011年 湖北省武汉市“3551人才计划” 特聘专家

2013年 湖北省“百人计划” 特聘专家